San Francisco, CA, June 2, 2010–African American men are known to be at a higher risk of developing prostate cancer, but according to Duke researchers they may also be at a greater risk of having more aggressive forms of the disease once it develops. New data on aggressive prostate cancer in African American men will be presented during the 105th Annual Scientific Meeting of the American Urological Association (AUA) and will be presented to the media during a special press conference on Wednesday, June 2, 2010. PDT.
Using biopsy specimens from 131 men (67 African American, 64 Caucasian) treated with radical prostatectomy at the Durham Veterans Affairs Medical Center, the researchers working with proprietary technology from Aureon Laboratories identified various putative biomarkers of progression [including the androgen receptor (AR), Ki-67 (a protein that can identify cells which are multiplying) and alpha-methylacyl CoA racemase (AMACR), a mitochondrial enzyme that is elevated in prostate cancer] in the needle biopsy samples. On multivariate analysis, all biomarkers were elevated in the African American group. The difference between the populations was statistically significant for AR, overall Ki67 and the amount of ki67 associated with different sized gland lumens.
“African American men are more than twice as likely to develop prostate cancer and these data show tumors may be more aggressive in this population,” said Anthony Y. Smith, MD, an AUA spokesman. “African American men should be especially vigilant about their prostate health and talk with their physicians about prostate cancer testing starting at age 40.”
NOTE TO REPORTERS: Experts are available to discuss this study outside normal briefing times. To arrange an interview with an expert, please contact the AUA Communications Office at the number above or e-mail Communications@AUAnet.org.
About the American Urological Association: Founded in 1902 and headquartered near Baltimore, Maryland, the American Urological Association is the pre-eminent professional organization for urologists, with more than 16,000 members throughout the world. An educational nonprofit organization, the AUA pursues its mission of fostering the highest standards of urologic care by carrying out a wide variety of programs for members and their patients.
Wendy Isett, AUA