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ORLANDO, FL, May 21, 2008 – Managing your cholesterol may also help you manage your prostate- specific antigen (PSA) level. Data presented today at the 103rd Annual Scientific Meeting of the American Urological Association from researchers at the Duke Prostate Center, Duke University explored the relationship between total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and PSA prior to beginning statin therapy. Data collected from a study of 1,214 men about to start cholesterol-lowering drugs (statins) between 1990 and 2006 at the Durham Veteran Affairs Medical Center in North Carolina shows that PSA levels were lower among men with lower total and LDL cholesterol levels. Researchers presented their findings to reporters in a special press conference on May 21, 2008 at 1:00 p.m.

In 2007, a retrospective study from the same group showed that men taking statins to lower their cholesterol also experienced a proportional decline in their PSA levels. This new study confirms that evidence and highlights the fact that cholesterol may play a role in prostate biology. Data was collected from men who were free of prostate cancer, had not undergone prostate surgery or taken medicine to alter androgen levels, and whose PSA was between 0.1 and 10.0 ng/ml.

“These findings further affirm the idea that a heart-healthy lifestyle can also be a prostate-healthy lifestyle,” said Stephen J. Freedland, M.D., one of the study’s authors. “Indeed, monitoring your cholesterol could be a means to keeping your PSA at a lower level.”

“Though the observed change in PSA across different cholesterol levels in this group of men is unlikely to impair the use of PSA to test for prostate cancer,” commented the study’s lead author, Dr. Robert J. Hamilton, M.D., M.P.H, “this issue clearly warrants further study.”  It remains to be seen whether or not lowering your PSA through statin medications could potentially mask the presence of prostate disease. The results of this study indicate that cholesterol and PSA are valuable indicators of overall health for men and should continue to be monitored together.

NOTE TO REPORTERS: Experts are available to discuss these studies outside normal briefing times. To arrange an interview with an expert, please contact the AUA Communications Office at the number above or e-mail Wendy Isett at

Hamilton RJ, Platz EA, Goldberg KC, Freedland SJ: The association between cholesterol and PSA. J Urol, suppl., 2008; 179: 721, abstract 2094.

About the American Urological Association: Founded in 1902 and headquartered near Baltimore, Maryland, the American Urological Association is the pre-eminent professional organization for urologists, with more than 15,000 members throughout the world. An educational nonprofit organization, the AUA pursues its mission of fostering the highest standards of urologic care by carrying out a wide variety of programs for members and their patients, including, an award-winning on-line patient education resource, and the American Urological Association Foundation, Inc.

Wendy Waldsachs Isett, AUA